Validation of the Bowman Perfusion Monitoring System: Continuous Real-time Perfusion Quantification

The flow measured by the perfusion probe has been validated for accuracy against flow measured by XeCT in humans1, hydrogen clearance in pigs2 and radioactive and non-radioactive micro-spheres in rat and rabbit livers3.  All probes are calibrated during the process of manufacture for zero flow condition of less than 0.2 ml/100g-min. The Bowman Perfusion Monitoring System is FDA cleared.

References:

(1) P. Vajkoczy, H. Roth, P. Horn, T. Lucke, C. Thome, U. Hubner, G. T. Martin, C. Zappletal, E. Klar, L. Schilling, and P. Schmiedek, “Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe,” Journal of neurosurgery, vol. 93, no. 2, pp. 265–274, Aug. 2000.

(2) E. Klar, T. Kraus, J. Bleyl, W.H. Newman, H.F. Bowman, W. Hofmann, R. von Kummer, M. Bredt, C. Herfarth, 1999, “Thermodiffusion for continuous quantification of hepatic microcirculation – Validation and Potentials in Liver Transplantation”, Microvascular Research, 58:156-166.

(3) G.T. Martin and H.F. Bowman. “Validation of Real-Time Continuous Perfusion Measurement.” Medical & Biological Engineering & Computing. 38(3): 319-326. 2000.