Published Literature

Emerging Literature consistently demonstrates that direct CBF monitoring provides more accurate and actionable insight into cerebral perfusion than indirect markers

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2025 1 citation

Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients

Briggs JK, Stroh JN, Park S, et al. Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients. bioRxiv [Preprint]. 2025 May 23. doi:10.1101/2025.05.22.655581.

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2025 6 citations

Characterizing the physiology of circulatory arrest in humans

Bird JD, Hornby L, Hirsch-Reinshagen V, et al. Characterizing the physiology of circulatory arrest in humans. Nature Medicine. 2025;31(10):3542-3552. doi:10.1038/s41591-025-03889-z.

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2025 0 citations

Binary Classification of Consciousness Using Cerebral Blood Flow and EEG Features

Azizi Zade F, Dar I, Foreman B, Sunar U. Binary Classification of Consciousness Using Cerebral Blood Flow and EEG Features. medRxiv [Preprint]. 2025 Dec 11. doi:10.64898/2025.12.09.25341792.

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2025 2 citations

The Historical and Clinical Foundations of the Modern Neuroscience Intensive Care Unit

Ader J, Twomey K, Fink ME, Ch'ang JH. The Historical and Clinical Foundations of the Modern Neuroscience Intensive Care Unit. World Neurosurgery. 2025;193:338-342. doi:10.1016/j.wneu.2024.09.119.

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2024 0 citations

Pressure, Compliance, and Autoregulation: Studies in Intracranial Dynamics

Pelah A. Pressure, Compliance, and Autoregulation: Studies in Intracranial Dynamics [dissertation]. Cambridge, UK: University of Cambridge; 2024.

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2024 0 citations

Oxygen-based autoregulation indices associated with clinical outcomes and spreading depolarization in aSAH

Carlson AP, Jones T, Zhu Y, Desai M, Alsarah A, Shuttleworth CW. Oxygen-based autoregulation indices associated with clinical outcomes and spreading depolarization in aSAH. medRxiv [Preprint]. 2024 May 18. doi:10.1101/2024.05.17.24307563.

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2024 4 citations

Focal brain oxygen, blood flow, and intracranial pressure measurements in relation to optimal cerebral perfusion pressure

Pelah AI, Czosnyka M, Menacho S, Nwachuku E, Hawryluk GWJ. Focal brain oxygen, blood flow, and intracranial pressure measurements in relation to optimal cerebral perfusion pressure. Journal of Neurosurgery. 2024;140(5):1423-1433. doi:10.3171/2023.8.JNS231519.

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2024 4 citations ★ Selected

Intracranial pressure-flow relationships in TBI patients expose gaps in the tenets of models and pressure-oriented management

Stroh J, Foreman B, Bennett TD, Briggs JK, Park S, Albers DJ. Intracranial pressure-flow relationships in traumatic brain injury patients expose gaps in the tenets of models and pressure-oriented management. medRxiv [Preprint]. 2024 Jan 18. doi:10.1101/2024.01.17.24301445.

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2024 3 citations ★ Selected

Vasopressin increases Cerebral Perfusion Pressure but not Cerebral Blood Flow in Neurosurgical Patients with Norepinephrine-Refractory Hypotension: A Preliminary Evaluation using the non-invasive Quantix ND in Comparison to the Literature

Bele S, Bründl E, Schmidt NO, Kieninger M. Vasopressin increases Cerebral Perfusion Pressure but not Cerebral Blood Flow in Neurosurgical Patients with Norepinephrine-Refractory Hypotension: A Preliminary Evaluation using the non-invasive Quantix ND in Comparison to the Literature. Research Square [Preprint]. 2024 Jan 9. doi:10.21203/rs.3.rs-3828021/v1.

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2023 2 citations

Cerebral microdialysis demonstrates improvements in brain metabolism with cerebrospinal fluid diversion in spontaneous intracerebral hemorrhage

Shah I, Chen PM, Tran DKT, Chen JW. Cerebral microdialysis demonstrates improvements in brain metabolism with cerebrospinal fluid diversion in spontaneous intracerebral hemorrhage. Surgical Neurology International. 2023;14:395. doi:10.25259/SNI_679_2023.

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2023 21 citations

Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process

Foreman B, Kapinos G, Wainwright MS, et al. Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process. Critical Care Medicine. 2023;51(12):1740-1753. doi:10.1097/CCM.0000000000006016.

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2022 34 citations

First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064 nm using superconducting nanowire single photon detectors in a neuro intensive care unit

Poon CS, Langri DS, Rinehart B, et al. First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064 nm using superconducting nanowire single photon detectors in a neuro intensive care unit. Biomedical Optics Express. 2022;13(3):1344. doi:10.1364/BOE.448135.

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2022 11 citations

Continuous intra-arterial nimodipine infusion as rescue treatment of severe refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Anthofer J, Bele S, Wendl C, et al. Continuous intra-arterial nimodipine infusion as rescue treatment of severe refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Journal of Clinical Neuroscience. 2022;96:163-171. doi:10.1016/j.jocn.2021.10.028.

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2022 4 citations ★ Selected

Correlation of intraventricular nicardipine for refractory vasospasm in aneurysmal subarachnoid hemorrhage with improved neurophysiology on intracranial multimodality monitoring: illustrative case

Grandhi R, Menacho ST, Ravindra VM, Condie C, Taussky P, Hawryluk GWJ. Correlation of intraventricular nicardipine for refractory vasospasm in aneurysmal subarachnoid hemorrhage with improved neurophysiology on intracranial multimodality monitoring: illustrative case. Journal of Neurosurgery: Case Lessons. 2022;3(22). doi:10.3171/case22113.

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2022 29 citations ★ Selected

The Relationship Between Seizures and Spreading Depolarizations in Patients with Severe Traumatic Brain

Foreman B, Lee H, Okonkwo DO, et al. The Relationship Between Seizures and Spreading Depolarizations in Patients with Severe Traumatic Brain Injury. Neurocritical Care. 2022;37(S1):31-48. doi:10.1007/s12028-022-01441-2.

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2021 13 citations

Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: physiological responses to continuous hypercapnia

Stetter C, Weidner F, Lilla N, et al. Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: physiological responses to continuous hypercapnia. Scientific Reports. 2021;11(1). doi:10.1038/s41598-021-91007-7.

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2021 13 citations

First Report of Spreading Depolarization Correlates on Scalp EEG Confirmed with a Depth Electrode

Robinson D, Hartings J, Foreman B. First Report of Spreading Depolarization Correlates on Scalp EEG Confirmed with a Depth Electrode. Neurocritical Care. 2021;35(S2):100-104. doi:10.1007/s12028-021-01360-8.

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2021 10 citations

Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report

Poon CS, Rinehart B, Langri DS, et al. Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report. Brain Sciences. 2021;11(8):1093. doi:10.3390/brainsci11081093.

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2020 20 citations

Protective Effects of Obstructive Sleep Apnea on Outcomes After Subarachnoid Hemorrhage: A Nationwide Analysis

Kaculini C, Wallace DJ, Haywood AE, et al. Protective Effects of Obstructive Sleep Apnea on Outcomes After Subarachnoid Hemorrhage: A Nationwide Analysis. Neurosurgery. 2020;87(5):1008-1015. doi:10.1093/neuros/nyaa242.

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2020 3 citations

Characterization of focal brain tissue water measurements in human traumatic brain injury

Kundu B, Awad AW, Park MS, Grandhi R, Enniss T, Hawryluk GWJ. Characterization of Focal Brain Tissue Water Measurements in Human Traumatic Brain Injury. World Neurosurgery. 2020;135:e271-e285. doi:10.1016/j.wneu.2019.11.132.

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2020 122 citations

Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury

Hartings JA, Andaluz N, Bullock MR, et al. Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury. JAMA Neurology. 2020;77(4):489. doi:10.1001/jamaneurol.2019.4476.

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2019 21 citations

Continuous Thermal Diffusion-Based Cerebral Blood Flow Monitoring in Adult Traumatic Brain Injury: A Scoping Systematic Review

Mathieu F, Khellaf A, Thelin EP, Zeiler FA. Continuous Thermal Diffusion-Based Cerebral Blood Flow Monitoring in Adult Traumatic Brain Injury: A Scoping Systematic Review. Journal of Neurotrauma. 2019;36(11):1707-1723. doi:10.1089/neu.2018.6309.

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2019 0 citations

Acute Brain Injury Is Associated With Prolonged Suppression of Cerebral Blood Flow Oscillations

Jamiolkowski RM, Baker W, Kofke AW, Balu R. Acute Brain Injury Is Associated With Prolonged Suppression of Cerebral Blood Flow Oscillations. Neurosurgery. 2019;66(Supplement 1):310-680. doi:10.1093/neuros/nyz310_680.

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2019 80 citations ★ Selected

Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain

Baker WB, Balu R, He L, et al. Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury. Journal of Cerebral Blood Flow & Metabolism. 2019;39(8):1469-1485. doi:10.1177/0271678x19846657.

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2018 26 citations ★ Selected

Intracortical electrophysiological correlates of blood flow after severe SAH: A multimodality monitoring study

Foreman B, Albers D, Schmidt JM, et al. Intracortical electrophysiological correlates of blood flow after severe SAH: A multimodality monitoring study. Journal of Cerebral Blood Flow & Metabolism. 2017;38(3):506-517. doi:10.1177/0271678x17700433.

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2018 44 citations

Safety and Reliability of Bedside, Single Burr Hole Technique for Intracranial Multimodality Monitoring in Severe Traumatic Brain Injury

Foreman B, Ngwenya LB, Stoddard E, Hinzman JM, Andaluz N, Hartings JA. Safety and Reliability of Bedside, Single Burr Hole Technique for Intracranial Multimodality Monitoring in Severe Traumatic Brain Injury. Neurocritical Care. 2018;29(3):469-480. doi:10.1007/s12028-018-0551-7.

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2017 30 citations ★ Selected

Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets

Coats B, Binenbaum G, Smith C, et al. Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets. Journal of Neurotrauma. 2017;34(1):235-247. doi:10.1089/neu.2015.4352.

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2016 10 citations ★ Selected

Causal Structure of Brain Physiology after Brain Injury from Subarachnoid Hemorrhage

Claassen J, Rahman SA, Huang Y, et al. Causal Structure of Brain Physiology after Brain Injury from Subarachnoid Hemorrhage. PLOS ONE. 2016;11(4):e0149878. doi:10.1371/journal.pone.0149878.

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2016 41 citations ★ Selected

Controlled hypercapnia enhances cerebral blood flow and brain tissue oxygenation after aneurysmal subarachnoid hemorrhage: results of a phase 1 study

Westermaier T, Stetter C, Kunze E, et al. Controlled Hypercapnia Enhances Cerebral Blood Flow and Brain Tissue Oxygenation After Aneurysmal Subarachnoid Hemorrhage: Results of a Phase 1 Study. Neurocritical Care. 2016;25(2):205-214. doi:10.1007/s12028-016-0246-x.

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2016 19 citations ★ Selected

Invasive seizure monitoring in the critically-Ill brain injury patient: Current practices and a review of the literature

Mikell CB, Dyster TG, Claassen J. Invasive seizure monitoring in the critically-Ill brain injury patient: Current practices and a review of the literature. Seizure. 2016;41:201-205. doi:10.1016/j.seizure.2016.05.017.

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2016 2 citations ★ Selected

Isoflurane rescue therapy for bronchospasm reduces intracranial pressure in a patient with traumatic brain injury

Gradisek P, Dolenc S. Isoflurane rescue therapy for bronchospasm reduces intracranial pressure in a patient with traumatic brain injury. Brain Injury. 2016;30(8):1035-1040. doi:10.3109/02699052.2016.1147598.

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2016 10 citations ★ Selected

Neuroglucopenia and Metabolic Distress in Two Patients with Viral Meningoencephalitis: A Microdialysis Study

Kofler M, Schiefecker A, Beer R, et al. Neuroglucopenia and Metabolic Distress in Two Patients with Viral Meningoencephalitis: A Microdialysis Study. Neurocritical Care. 2016;25(2):273-281. doi:10.1007/s12028-016-0272-8.

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2016 13 citations ★ Selected

Novel Method for Dynamic Control of Intracranial

Luciano MG, Dombrowski SM, Qvarlander S, et al. Novel method for dynamic control of intracranial pressure. Journal of Neurosurgery. 2017;126(5):1629-1640. doi:10.3171/2016.4.jns152457.

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2016 20 citations ★ Selected

The Utility of Cerebral Blood Flow Assessment in TBI

Akbik OS, Carlson AP, Krasberg M, Yonas H. The Utility of Cerebral Blood Flow Assessment in TBI. Current Neurology and Neuroscience Reports. 2016;16(8). doi:10.1007/s11910-016-0672-3.

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2015 19 citations ★ Selected

Assessment of Cerebrovascular Autoregulation Using Regional Cerebral Blood Flow in Surgically Managed Brain Trauma Patients

Tackla R, Hinzman JM, Foreman B, Magner M, Andaluz N, Hartings JA. Assessment of Cerebrovascular Autoregulation Using Regional Cerebral Blood Flow in Surgically Managed Brain Trauma Patients. Neurocritical Care. 2015;23(3):339-346. doi:10.1007/s12028-015-0146-5.

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2015 46 citations ★ Selected

Continuous intra-arterial nimodipine infusion in patients with severe refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a feasibility study and outcome results

Bele S, Proescholdt MA, Hochreiter A, et al. Continuous intra-arterial nimodipine infusion in patients with severe refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a feasibility study and outcome results. Acta Neurochirurgica. 2015;157(12):2041-2050. doi:10.1007/s00701-015-2597-z.

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2015 58 citations

Is local hypoperfusion the reason for transient neurological deficits after STA-MCA bypass for moyamoya disease?

Mukerji N, Cook DJ, Steinberg GK. Is local hypoperfusion the reason for transient neurological deficits after STA-MCA bypass for moyamoya disease? Journal of Neurosurgery. 2015;122(1):90-94. doi:10.3171/2014.8.JNS132413.

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2014 1 citation ★ Selected

A Novel Use of Transfer Function Estimation for Early Assessment of Brain Injury Outcome

Svenkeson D, Sena B, Oishi M, Pappu S, Yonas H. A Novel Use of Transfer Function Estimation for Early Assessment of Brain Injury Outcome. IEEE Transactions on Biomedical Engineering. 2014;61(9):2413-2421. doi:10.1109/tbme.2014.2317942.

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2014 0 citations ★ Selected

Brain Tissue Perfusion Monitoring

Panczykowski DM, Shutter L. Brain Tissue Perfusion Monitoring. In: Neurocritical Care Monitoring. Springer Publishing Company. doi:10.1891/9781617051883.0005.

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2014 146 citations ★ Selected

Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma

Hinzman JM, Andaluz N, Shutter LA, et al. Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma. Brain. 2014;137(11):2960-2972. doi:10.1093/brain/awu241.

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2014 9 citations

Perihemorrhagic Ischemia Occurs in a Volume-Dependent Manner as Assessed by Multimodal Cerebral Monitoring in a Porcine Model of Intracerebral Hemorrhage

Orakcioglu B, Kentar MM, Schiebel P, Uozumi Y, Unterberg A, Sakowitz OW. Perihemorrhagic Ischemia Occurs in a Volume-Dependent Manner as Assessed by Multimodal Cerebral Monitoring in a Porcine Model of Intracerebral Hemorrhage. Neurocritical Care. 2014;22(1):133-139. doi:10.1007/s12028-014-0027-3.

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2014 34 citations ★ Selected

Post-traumatic multimodal brain monitoring: response to hypertonic

Dias C, Silva MJ, Pereira E, et al. Post-Traumatic Multimodal Brain Monitoring: Response to Hypertonic Saline. Journal of Neurotrauma. 2014;31(22):1872-1880. doi:10.1089/neu.2014.3376.

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2014 3 citations

Role of Microvascular Shunts in the Loss of Cerebral Blood Flow

Nemoto EM, Bragin DE, Statom G, et al. Role of Microvascular Shunts in the Loss of Cerebral Blood Flow Autoregulation. In: Advances in Experimental Medicine and Biology. Springer New York; 2014:43-49. doi:10.1007/978-1-4939-0620-8_6.

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2013 105 citations ★ Selected

Beyond intracranial pressure: optimization of cerebral blood flow, oxygen, and substrate delivery after traumatic brain injury

Bouzat P, Sala N, Payen JF, Oddo M. Beyond intracranial pressure: optimization of cerebral blood flow, oxygen, and substrate delivery after traumatic brain injury. Annals of Intensive Care. 2013;3(1):23. doi:10.1186/2110-5820-3-23.

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2013 16 citations

Cerebral Blood Flow Dynamics and Head-of-Bed Changes in the Setting of Subarachnoid Hemorrhage

Kung DK, Chalouhi N, Jabbour PM, et al. Cerebral Blood Flow Dynamics and Head-of-Bed Changes in the Setting of Subarachnoid Hemorrhage. BioMed Research International. 2013;2013:1-4. doi:10.1155/2013/640638.

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2013 40 citations ★ Selected

Multimodality Monitoring in the Neurointensive Care Unit: A Special Perspective for Patients with Stroke

Ko SB. Multimodality Monitoring in the Neurointensive Care Unit: A Special Perspective for Patients with Stroke. Journal of Stroke. 2013;15(2):99. doi:10.5853/jos.2013.15.2.99.

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2013 26 citations

Neuromonitoring with Microdialysis in Severe Traumatic Brain Injury Patients

Sanchez JJ, Bidot CJ, O’Phelan K, et al. Neuromonitoring with Microdialysis in Severe Traumatic Brain Injury Patients. In: Acta Neurochirurgica Supplement. Springer Vienna; 2013:223-227. doi:10.1007/978-3-7091-1434-6_42.

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2013 172 citations ★ Selected

Nonconvulsive seizures after subarachnoid hemorrhage: Multimodal detection and outcomes

Claassen J, Perotte A, Albers D, et al. Nonconvulsive seizures after subarachnoid hemorrhage: Multimodal detection and outcomes. Annals of Neurology. 2013;74(1):53-64. doi:10.1002/ana.23859.

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2013 36 citations ★ Selected

Pressures, Flow, and Brain Oxygenation During Plateau Waves of Intracranial

Dias C, Maia I, Cerejo A, et al. Pressures, Flow, and Brain Oxygenation During Plateau Waves of Intracranial Pressure. Neurocritical Care. 2013;21(1):124-132. doi:10.1007/s12028-013-9918-y.

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2013 0 citations

Subarachnoid Hemorrhage: Critical Care Management

Abate MG, Citerio G. Subarachnoid Hemorrhage: Critical Care Management. In: Annual Update in Intensive Care and Emergency Medicine 2013. Springer Berlin Heidelberg; 2013:765-779. doi:10.1007/978-3-642-35109-9_60.

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2013 21 citations

The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model

Bruins B, Kilbaugh TJ, Margulies SS, Friess SH. The Anesthetic Effects on Vasopressor Modulation of Cerebral Blood Flow in an Immature Swine Model. Anesthesia & Analgesia. 2013;116(4):838-844. doi:10.1213/ane.0b013e3182860fe7.

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2012 57 citations

Brain multimodality monitoring: an update

Oddo M, Villa F, Citerio G. Brain multimodality monitoring. Current Opinion in Critical Care. 2012;18(2):111-118. doi:10.1097/mcc.0b013e32835132a5.

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2012 15 citations

Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model

Friess SH, Smith C, Kilbaugh TJ, et al. Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model. Critical Care Medicine. 2012;40(8):2400-2406. doi:10.1097/ccm.0b013e31825333e6.

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2012 70 citations ★ Selected

Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: effects on regional cerebral blood flow

Villa F, Iacca C, Molinari AF, et al. Inhalation versus endovenous sedation in subarachnoid hemorrhage patients. Critical Care Medicine. 2012;40(10):2797-2804. doi:10.1097/ccm.0b013e31825b8bc6.

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2011 82 citations

Cyclosporin A Preserves Mitochondrial Function after Traumatic Brain Injury in the Immature Rat and Piglet

Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A Preserves Mitochondrial Function after Traumatic Brain Injury in the Immature Rat and Piglet. Journal of Neurotrauma. 2011;28(5):763-774. doi:10.1089/neu.2010.1635.

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2011 2 citations

Dynamic Autoregulation Testing Does Not Indicate Changes of Cerebral Blood Flow Before and After Resection of Small- and Medium-Sized Cerebral AVM

Stüer C, Ikeda T, Stoffel M, Schaller C, Meyer B. Dynamic Autoregulation Testing Does Not Indicate Changes of Cerebral Blood Flow Before and After Resection of Small- and Medium-Sized Cerebral AVM. Translational Stroke Research. 2010;2(1):60-66. doi:10.1007/s12975-010-0031-7.

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2011 112 citations ★ Selected

Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe TBI

Rosenthal G, Sanchez-Mejia RO, Phan N, Hemphill JC, Martin C, Manley GT. Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. Journal of Neurosurgery. 2011;114(1):62-70. doi:10.3171/2010.6.jns091360.

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2011 7 citations

Modified flow- and oxygen-related autoregulation indices for continuous monitoring of cerebral

Hecht N, Fiss I, Wolf S, Barth M, Vajkoczy P, Woitzik J. Modified flow- and oxygen-related autoregulation indices for continuous monitoring of cerebral autoregulation. Journal of Neuroscience Methods. 2011;201(2):399-403. doi:10.1016/j.jneumeth.2011.08.018.

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2011 13 citations ★ Selected

Multimodal Neuromonitoring in a Patient with Aneurysmal Subarachnoid Hemorrhage Associated with Aortic Coarctation

Helbok R, Beer R, Chemelli A, et al. Multimodal Neuromonitoring in a Patient with Aneurysmal Subarachnoid Hemorrhage Associated with Aortic Coarctation. Neurocritical Care. 2011;14(3):433-437. doi:10.1007/s12028-011-9503-1.

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2011 4 citations

Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH

Orakcioglu B, Kentar M, Uozumi Y, et al. Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH. In: Acta Neurochirurgica Supplementum. Springer Vienna; 2011:19-23. doi:10.1007/978-3-7091-0693-8_4.

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2011 45 citations

Status epilepticus-induced hyperemia and brain tissue hypoxia after cardiac arrest

Ko SB. Status Epilepticus–Induced Hyperemia and Brain Tissue Hypoxia After Cardiac Arrest. Archives of Neurology. 2011;68(10):1323. doi:10.1001/archneurol.2011.240.

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2010 46 citations ★ Selected

Continuous Selective Intraarterial Infusion of Nimodipine for Therapy of Refractory Cerebral

Wolf S, Martin H, Landscheidt JF, Rodiek SO, Schürer L, Lumenta CB. Continuous Selective Intraarterial Infusion of Nimodipine for Therapy of Refractory Cerebral Vasospasm. Neurocritical Care. 2009;12(3):346-351. doi:10.1007/s12028-009-9317-6.

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2009 71 citations ★ Selected

Clinical evaluation of the safety and efficacy of lumbar cerebrospinal fluid drainage for the treatment of refractory increased intracranial pressure

Tuettenberg J, Czabanka M, Horn P, et al. Clinical evaluation of the safety and efficacy of lumbar cerebrospinal fluid drainage for the treatment of refractory increased intracranial pressure. Journal of Neurosurgery. 2009;110(6):1200-1208. doi:10.3171/2008.10.jns08293.

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2009 10 citations

Refining Resuscitation Strategies Using Tissue Oxygen and Perfusion Monitoring in Critical Organ Beds

Wan JJ, Cohen MJ, Rosenthal G, et al. Refining Resuscitation Strategies Using Tissue Oxygen and Perfusion Monitoring in Critical Organ Beds. Journal of Trauma: Injury, Infection & Critical Care. 2009;66(2):353-357. doi:10.1097/ta.0b013e318195e222.

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2008 7 citations

Brain tissue oxygen monitors: More than an ischemia monitor*

Oddo M, Le Roux P. Brain tissue oxygen monitors: More than an ischemia monitor. Critical Care Medicine. 2008;36(6):1984-1985. doi:10.1097/ccm.0b013e318176a9f6.

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2008 217 citations ★ Selected

Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury

Rosenthal G, Hemphill JC, Sorani M, et al. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Critical Care Medicine. 2008;36(6):1917-1924. doi:10.1097/ccm.0b013e3181743d77.

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2008 21 citations

Evaluation of a bedside monitor of regional CBF as a measure of CO2 reactivity in neurosurgical intensive care patients

Soukup J, Bramsiepe I, Brucke M, Sanchin L, Menzel M. Evaluation of a Bedside Monitor of Regional CBF as a Measure of CO2 Reactivity in Neurosurgical Intensive Care Patients. Journal of Neurosurgical Anesthesiology. 2008;20(4):249-255. doi:10.1097/ana.0b013e31817ef487.

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2008 0 citations ★ Selected

Quantification of transient ischemic and metabolic events in patients after subarachnoid haemorrhage

Sakowitz OW, Krajewski KL, Haux D, Orakcioglu B, Unterberg AW, Kiening KL. Quantification of transient ischemic and metabolic events in patients after subarachnoid haemorrhage. In: Acta Neurochirurgica Supplement. Springer Vienna; 2008:395-397. doi:10.1007/978-3-211-75718-5_83.

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2007 248 citations

Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage

Muench E, Horn P, Bauhuf C, et al. Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage. Critical Care Medicine. 2007;35(8):1844-1851. doi:10.1097/01.ccm.0000275392.08410.dd.

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2007 30 citations ★ Selected

Effects of the selective endothelin A (ETA) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage – preliminary results from a randomized clinical series

Barth M, Capelle HH, Münch E, et al. Effects of the selective endothelin A (ETA) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage – preliminary results from a randomized clinical series. Acta Neurochirurgica. 2007;149(9):911-918. doi:10.1007/s00701-007-1249-3.

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2007 5 citations

Endothelin-1 and cerebral blood flow in a porcine model

Henze D, Menzel M, Soukup J, et al. Endothelin-1 and cerebral blood flow in a porcine model. Journal of Clinical Neuroscience. 2007;14(7):650-657. doi:10.1016/j.jocn.2006.05.017.

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2007 29 citations ★ Selected

Great toe-to-thumb microvascular transplantation after traumatic amputation

Buncke GM, Buncke HJ, Lee CK. Great Toe-to-Thumb Microvascular Transplantation After Traumatic Amputation. Hand Clinics. 2007;23(1):105-115. doi:10.1016/j.hcl.2007.01.007.

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2007 4 citations

Monitoring Cerebral Blood Flow in Neurosurgical Intensive

Vajkoczy P, Schomacher M, Czabanka M, Horn P. Monitoring Cerebral Blood Flow in Neurosurgical Intensive Care. European Neurological Review. 2007:6. doi:10.17925/enr.2007.00.02.6.

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2007 90 citations

Multimodality monitoring in neurocritical care

Wartenberg KE, Schmidt JM, Mayer SA. Multimodality Monitoring in Neurocritical Care. Critical Care Clinics. 2007;23(3):507-538. doi:10.1016/j.ccc.2007.06.002.

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2006 9 citations ★ Selected

Current advances in the diagnosis of vasospasm

Munch E, Vajkoczy P. Current advances in the diagnosis of vasospasm. Neurological Research. 2006;28(7):703-712. doi:10.1179/016164106x151981.

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2005 128 citations

Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen

Jaeger M, Soehle M, Schuhmann MU, Winkler D, Meixensberger J. Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen. Acta Neurochirurgica. 2004;147(1):51-56. doi:10.1007/s00701-004-0408-z.

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2005 150 citations ★ Selected

Effects of Positive End-Expiratory Pressure on Regional Cerebral Blood Flow, Intracranial Pressure, and Brain Tissue

Muench E, Bauhuf C, Roth H, et al. Effects of positive end-expiratory pressure on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation. Critical Care Medicine. 2005;33(10):2367-2372. doi:10.1097/01.ccm.0000181732.37319.df.

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2005 17 citations

Thermal Diffusion Probe Analysis of Perfusion Changes in Vascular Occlusions of Rabbit Pedicle

Khot MB, Maitz PKM, Phillips BR, Bowman HF, Pribaz JJ, Orgill DP. Thermal Diffusion Probe Analysis of Perfusion Changes in Vascular Occlusions of Rabbit Pedicle Flaps. Plastic and Reconstructive Surgery. 2005;115(4):1103-1109. doi:10.1097/01.prs.0000156546.45229.84.

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2004 34 citations ★ Selected

Influence of moderate and profound hyperventilation on cerebral blood flow , oxygenation and metabolism

Clausen T, Scharf A, Menzel M, et al. Influence of moderate and profound hyperventilation on cerebral blood flow, oxygenation and metabolism. Brain Research. 2004;1019(1-2):113-123. doi:10.1016/j.brainres.2004.05.099.

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2003 170 citations ★ Selected

Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage

Vajkoczy P, Horn P, Thome C, Munch E, Schmiedek P. Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery. 2003;98(6):1227-1234. doi:10.3171/jns.2003.98.6.1227.

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2001 6 citations

Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygen

Hemphill JC, Knudson MM, Derugin N, Morabito D, Manley GT. Carbon Dioxide Reactivity and Pressure Autoregulation of Brain Tissue Oxygen. Neurosurgery. 2001;48(2):377-384. doi:10.1227/00006123-200102000-00028.

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2001 4 citations

Characterization of renal parenchymal perfusion during experimental infrarenal aortic clamping and declamping with enhanced thermodiffusion

Kraus T, Mehrabi A, Angelescu M, Golling M, Allenberg JR, Klar E. Characterization of Renal Parenchymal Perfusion during Experimental Infrarenal Aortic Clamping and Declamping with Enhanced Thermodiffusion Electrodes. Annals of Vascular Surgery. 2001;15(4):447-456. doi:10.1007/s100160010121.

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2001 49 citations ★ Selected

Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery

Thomé C, Vajkoczy P, Horn P, Bauhuf C, Hübner U, Schmiedek P. Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery. Journal of Neurosurgery. 2001;95(3):402-411. doi:10.3171/jns.2001.95.3.0402.

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2001 100 citations ★ Selected

Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral

Vajkoczy P, Horn P, Bauhuf C, et al. Effect of Intra-Arterial Papaverine on Regional Cerebral Blood Flow in Hemodynamically Relevant Cerebral Vasospasm. Stroke. 2001;32(2):498-505. doi:10.1161/01.str.32.2.498.

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2001 43 citations

Xenon-induced flow activation in patients with cerebral insult who undergo xenon-enhanced CT blood flow

Horn P, Vajkoczy P, Thomé C, Muench E, Schilling L, Schmiedek P.

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2000 0 citations

Correlation of Continuously Measured Regional Cerebral Blood Flow and Tissue Partial Oxygen Pressure during Periods of Increasing Intracranial Pressure

Geletneky K, Hashemi B, et al. 2000.

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2000 12 citations

Effects of 30% stable xenon on regional cerebral blood flow in patients with intracranial pathology

Horn P, Vajkoczy P, Thomé C, et al.

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2000 4 citations

Effects of exogenous endothelin-1 application on liver perfusion in native and transplanted porcine livers

Kraus T, Mehrabi A, Golling M, et al. Effects of Exogenous Endothelin-1 Application on Liver Perfusion in Native and Transplanted Porcine Livers. Journal of Surgical Research. 2000;93(2):272-281. doi:10.1006/jsre.2000.5972.

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2000 19 citations

Intrathecal Sodium Nitroprusside Improves Cerebral Blood Flow and Oxygenation in Refractory Cerebral Vasospasm and Ischemia in Humans

Vajkoczy P, Hubner U, Horn P, et al. Intrathecal Sodium Nitroprusside Improves Cerebral Blood Flow and Oxygenation in Refractory Cerebral Vasospasm and Ischemia in Humans. Stroke. 2000;31(5):1194-1198. doi:10.1161/01.str.31.5.1194-b.

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2000 18 citations

Validation of Real-Time Continuous Perfusion Measurement

Martin GT, Bowman HF. Validation of real-time continuous perfusion measurement. Medical & Biological Engineering & Computing. 2000;38(3):319-325. doi:10.1007/bf02347053.

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1999 28 citations

Assessment of hepatic perfusion in pigs by pharmacokinetic analysis of dynamic MR images

Scharf J, Zapletal C, Hess T, et al. Assessment of hepatic perfusion in pigs by pharmacokinetic analysis of dynamic MR images. Journal of Magnetic Resonance Imaging. 1999;9(4):568-572. doi:10.1002/(sici)1522-2586(199904)9:4<568::aid-jmri10>3.0.co;2-1.

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1999 2 citations

Cut-off value in thermodiffusion-assisted intrahepatic flow measurements after experimental liver

Weiss G, Golling M, Mehrabi A, et al. Cut-off value in thermodiffusion-assisted intrahepatic flow measurements after experimental liver transplantation. Transplantation Proceedings. 1999;31(8):3247-3249. doi:10.1016/s0041-1345(99)00712-5.

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1999 7 citations

Impairment of hepatic microcirculation as an early manifestation of acute rejection after clinical liver

Klar E, Angelescu M, Zapletal C, Kraus T, Herfarth C. Impairment of hepatic microcirculation as an early manifestation of acute rejection after clinical liver transplantation. Transplantation Proceedings. 1999;31(1-2):385-387. doi:10.1016/s0041-1345(98)01673-x.

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1999 29 citations

Thermodiffusion for Continuous Quantification of Hepatic Microcirculation—Validation and Potential in Liver Transplantation

Klar E, Kraus T, Bleyl J, et al. Thermodiffusion for Continuous Quantification of Hepatic Microcirculation—Validation and Potential in Liver Transplantation. Microvascular Research. 1999;58(2):156-166. doi:10.1006/mvre.1999.2166.

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1998 4 citations

Experimental evaluation of dynamic MRI for quantifying liver perfusion

Zapletal C, Mehrabi A, Scharf J, et al. Experimental evaluation of dynamic MRI for quantification of liver perfusion. Transplantation Proceedings. 1999;31(1-2):421-422. doi:10.1016/s0041-1345(98)01688-1.

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1998 6 citations

Hepatocellular injury early after reperfusion is correlated with liver microcirculation and predicts outcome after transplantation

Maksan SM, Kraus T, Hofmann WJ, et al. Hepatocellular injury early after reperfusion is correlated with liver microcirculation and predicts outcome after transplantation. Transplantation Proceedings. 1998;30(7):3716-3717. doi:10.1016/s0041-1345(98)01207-x.

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1998 9 citations

Quantification of hepatic microcirculation and intrahepatic shunt perfusion during experimental liver transplantation

Mehrabi A, Kraus T, Otto G, et al. Quantification of Hepatic Microcirculation and Intrahepatic Shunt Perfusion During Experimental Liver Transplantation. Transplantation Proceedings. 1998;30(3):794-796. doi:10.1016/s0041-1345(98)00052-9.

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1997 24 citations

Early assessment of reperfusion injury by intraoperative quantification of hepatic microcirculation in patients

Klar E, Bredt M, Kraus T, et al. Early assessment of reperfusion injury by intraoperative quantification of hepatic microcirculation in patients. Transplantation Proceedings. 1997;29(1-2):362-363. doi:10.1016/s0041-1345(96)00120-0.

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1997 8 citations

Perioperative monitoring of the cortical microcirculation in clinical renal transplantation by thermodiffusion

Angelescu M, Bredt M, Kraus T, Weber C, Wiesel M, Klar E. Perioperative monitoring of the cortical microcirculatiorn in clinical renal transplantation by thermodiffusion. Transplantation Proceedings. 1997;29(7):2790-2792. doi:10.1016/s0041-1345(97)00677-5.

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1996 26 citations ★ Selected

First clinical realization of continuous monitoring of liver microcirculation after transplantation by thermodiffusion

Klar E, Kraus T, Bredt M, et al. First clinical realization of continuous monitoring of liver microcirculation after transplantation by thermodiffusion. Transplant International. 1996;9(s1):S140-S143. doi:10.1111/j.1432-2277.1996.tb01591.x.

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1995 0 citations

A Methodology for in Vivo Measurement of Blood Flow in Small Tissue Volumes

Newman WH, Bowman HF, Orgill DP, Klar E. A Methodology for In Vivo Measurement of Blood Flow in Small Tissue Volumes. Advances in Heat and Mass Transfer in Biotechnology. 1995:99-105. doi:10.1115/imece1995-1302.

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1995 31 citations

Thermodiffusion as a novel method for continuous monitoring of the hepatic microcirculation after liver transplantation

Klar E, Kraus T, Bleyl J, et al.

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1991 9 citations

Tumor hyperthermia. Dense thermometry, dosimetry, and effects of perfusion-5-1991-01

Bowman HF, Newman WH, et al.

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1984 36 citations

An isolated rat liver model for the evaluation of thermal techniques to quantify perfusion

Valvano JW, Allen JT, Walsh JT, et al. An Isolated Rat Liver Model for the Evaluation of Thermal Techniques to Quantify Perfusion. Journal of Biomechanical Engineering. 1984;106(3):187-191. doi:10.1115/1.3138481.

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1984 42 citations

Estimation of Tissue Blood Flow

Bowman HF. In: Shitzer A, ed.

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1982 70 citations

Heat transfer mechanisms and thermal dosimetry

National Cancer Institute Monograph

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1980 11 citations

THE BIO-HEAT TRANSFER EQUATION and DISCRIMINATION OF THERMALLY SIGNIFICANT

Bowman HF. THE BIO‐HEAT TRANSFER EQUATION and DISCRIMINATION OF THERMALLY SIGNIFICANT VESSELS. Annals of the New York Academy of Sciences. 1980;335(1):155-160. doi:10.1111/j.1749-6632.1980.tb50744.x.

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1977 110 citations

Thermal Conductivity and Thermal Diffusivity of Biomaterials: A Simultaneous Measurement Technique

Balasubramaniam TA, Bowman HF. Thermal Conductivity and Thermal Diffusivity of Biomaterials: A Simultaneous Measurement Technique. Journal of Biomechanical Engineering. 1977;99(3):148-154. doi:10.1115/1.3426282.

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1976 15 citations

A new technique utilizing thermistor probes for the measurement of thermal properties of biomaterials

Bowman HF, Balasubramaniam TA. A new technique utilizing thermistor probes for the measurement of thermal properties of biomaterials. Cryobiology. 1976;13(5):572-580. doi:10.1016/0011-2240(76)90150-4.

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1975 217 citations

Theory, measurement, and application of thermal properties of biomaterials

Bowman HF, Cravalho EG, Woods M. Theory, Measurement, and Application of Thermal Properties of Biomaterials. Annual Review of Biophysics and Bioengineering. 1975;4(1):43-80. doi:10.1146/annurev.bb.04.060175.000355.

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